In our “Gold” offer, we bundle the tests of the MTHFR gene C677T mutation, the Leiden-mutation of the V. coagulation factor, and the analysis of the nucleotide in the -13910 position of the LCT gene.
80% of the hereditary predisposition to thrombosis cases are associated with the Leiden mutation. This alteration is very frequent in Hungary, approx. 10% of the population carries it. This means that in these cases only one of the two copies of the gene harbours the mutation, but even this is enough to raise thrombosis susceptibility 8-fold. If both of the copies are mutant, your risk increases 80-fold, provided no more risk factors are present.
Lactose intolerance in Hungary is present in 30-40% of the total population, which means they cannot digest lactose (a form of sugar in milk), or they have problems with its utilization. If you suspect you have lactose intolerance, or you want to know whether you can pass on the susceptibility to your children we advise you to take this test.
Our “Diamond” or medium offer gives you more than the “Gold”, by adding the analysis of Prothrombin or coagulation factor II to the thrombosis predisposition genes. The alteration in this gene raise the risk of thrombosis 3-fold. With this addition, the bundled test includes all the genes commonly analysed for predisposition to thrombosis.
The most common pathogenic mutation in the BRCA1 gene is 5266dupC. If somebody carries a pathogenic mutation in the BRCA1 gene, then her chances of developing breast cancer till the age of 75 are 55-88%, while her chances of developing ovarian cancer are 26-48%.
The CFTR gene’s most common pathogenic allele is ΔF508del. Cystic fibrosis is the most common disease with a genetic background. Every 28th person in the Caucasian population carries a copy of a mutant allele. They have 50% chance of passing on that copy to their children. Furthermore, even a single mutant copy can be in the background of male infertility.
With our “Platinum” offer, besides the thrombosis susceptibility and lactose intolerance genes, you can get the CFTR (for men) and the BRCA1 and BRCA2 (for women) genes examined at more mutation hotspots.
We analyse the 5 most frequent mutations in the BRCA 1 and BRCA2 genes (BRCA1: C61G, 185delAG, and 5382insC, BRCA2: 6174delT and 9326insA), or the 5 most common mutations in the CFTR gene (ΔF508del, R553X, G542X, W1282X, and N1303K). With this analysis, 65-70% of all occurrences are covered in the case of hereditary breast and ovarian cancers, while in the case of cystic fibrosis this number is 75-80%..